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portant; word-wrap: break-word !important;">如此惬意的晚年生活，是许多人梦想中的样子！然而，天有不测风云，由于经常咳嗽，吃了药也不见好转，最后去医院检查后，王先生被诊断为肺癌。

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portant; word-wrap: break-word !important;">具体而言是小细胞肺癌。原发部位是肺，肝脏也有转移，已经属于广泛期（即晚期）。

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portant; word-wrap: break-word !important;">首先，他的症状有咳嗽和血栓。由于也观察到胸痛和厌食等主观症状，立即开始用化疗药物（铂类+依托泊苷）治疗。

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一般而言，小细胞肺癌对化疗非常敏感，化疗一两个疗程结束后肿瘤可能就会消失，无进展生存率高达80%以上。但是，由于疾病特征，小细胞肺癌的复发风险极高，会出现不得不多次进行反复化疗。除极早期病例外，几乎都无法手术。

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因此，化疗药物是首选。但不幸的是，副作用非常大，王先生的治疗过程很艰难，被病痛及治疗折磨得苦不堪言。

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portant; word-wrap: break-word !important;">后来，王先生想放弃化疗，并咨询了他的主治医生，可否尝试高度活化的NK细胞治疗。医生问道：“你是想尝试化疗药物联合高度活化的NK细胞疗法共同治疗吗？” 

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患者希望能尽快缓解病痛，答到是想这样尝试的！在医生的详尽计划后，王先生开始联合化疗药物和高度活化的NK细胞疗法。

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portant; word-wrap: break-word !important;">第一次复查后，医生说：如果你看一下影像片子，你可以看到令人惊讶的治疗结果。之前出现白色的病变部位，在两个月后消失到几乎看不见的程度。”

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portant; word-wrap: break-word !important;">医生也很兴奋：“我以前从未见过恢复如此好的先例。”

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portant; word-wrap: break-word !important;">此外，王先生身体状况的恢复是显着的，不仅胸部疼痛消失，而且食欲也出现好转，能够自理很多事情。咳嗽和血凝块消失，痰液测试变为阴性。

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治疗1个月后，肿瘤标志物AFP正常，半年后NSE和CEA正常。

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高度活化的NK细胞联合化疗治疗开始一年后，不仅所有肿瘤标志物都正常，而且肺部肿瘤和肝脏肿瘤都消失了。

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portant; word-wrap: break-word !important;">在这种情况下，王先生获得了癌症治疗的重大突破，各项检查结果显示癌症已经消失了！但他表示仍要继续使用高度活化的NK细胞疗法，即使影像报告显示没有癌症迹象。

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王先生说道：“高度活化的NK细胞不仅治疗了我的癌症，更重要的是不断改善我的免疫系统，以防止癌症再次复发。所以，我要预防性治疗，即使治疗频率会减少，但我认为它非常有效。”

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癌症之所以难治疗，原因是复发风险高且易转移。出于预防目的，即使没有癌症迹象，也需警惕复发，不能掉以轻心。

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因为正视自己的病情，且积极配合治疗，有着良好的生活态度，王先生各方面都很慎重，包括治疗和预防复发，随访至今仍处于良好状态。

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吸取治疗经验

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">王先生的肿瘤消失，体征恢复正常，不能忽视高度活化的NK细胞疗法的功劳。因为目前，转移性小细胞肺癌的标准治疗方案是，含铂化疗，必要时进行放疗减小局部病灶，降低肿瘤负荷。

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">但基于标准疗法的有效性，大量临床数据显示，转移性小细胞肺癌的平均存活期为6-8个月！像王先生这样的病情，肿瘤病灶能够消失，堪称奇迹！

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">这样的治疗奇迹是不是可以复制到所有的肺癌患者身上，您就要来彻底了解一下，王先生额外的选择的高度活化的NK细胞疗法的来龙去脉了！也通过400——626——9916知道更多关于高度活化的NK细胞疗法的信息。

初识NK细胞，守住人体第一道防线！

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">看了王先生的成功抗癌经历，相信很多病友都想知道她接受的高度活化的NK细胞疗法究竟是何方神圣，自己是不是适合，我们先来了解一下NK细胞的前世今生。

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">NK细胞又称自然杀伤细胞，是人体第三类淋巴细胞，其表面缺少T细胞和B细胞的特异性标志如TCR和Smlg，曾称为裸细胞。NK细胞最厉害的地方是，不需要抗原递呈过程，不用别人通风报信，就可以直接、快速将外来异物（病毒细菌感染细胞、癌细胞、衰老细胞等）就地正法。在人外周血中占淋巴细胞的5%-10%，作为免疫系统的核心部分，是人体内最有价值的先天性免疫细胞。

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seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">NK细胞可以抑制细菌和病毒入侵，清除癌变、病变、衰老细胞，具有预防癌症和延缓机体衰老的功效，已被医学界公认为“人体的第一道屏障”、血液的清道夫。时时刻刻坚守岗位，随着血液循环监控身体的异常。

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">它就是我们血液的巡警，游弋在血液中，分布于全身各器官，一旦发现细菌、病毒和体内病变、癌变、衰老的细胞，便实施免疫攻击，同时活化其他免疫细胞，共同作战，杀伤和清除体内的有害细胞。

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">循环中的NK细胞通常处于休眠状态，一旦被外来刺激活化后，它们会渗透到大多数组织中攻击肿瘤细胞和病毒感染的细胞。NK细胞不同于T细胞，它不需抗体存在或抗原致敏，即可杀伤某些肿瘤细胞或病毒感染的细胞，也就是说，冲在战斗第一线的肯定是NK细胞。

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什么是高度活化NK细胞疗法？

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">实际上，NK细胞被认为是机体抗感染，抗肿瘤的第一道天然防线，是机体杀癌效果最强的免疫细胞。他们可以迅速进行防御并直接攻击肿瘤细胞，并且与T细胞不同，NK细胞起效快，也不会对受体组织造成移植物抗宿主病。但NK细胞在体内含量较少，仅占白细胞的10％。并且随着年龄的上升，免疫力下降，NK细胞数量变得更少，而肿瘤患者及肿瘤术后患者体内NK细胞的数量及活性都发生了一定的改变，更加不能非常有效地发挥抗癌作用。

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">为了提高体内NK细胞的活性及数量，日本的科学家发明了一种亿万倍增法，是从人体血液当中抽取50ml，把极少量的NK细胞分离出来再扩增培养，使其数量增加到原来的1000倍，数量达到10亿-50亿个，再回输体内，大量的NK细胞会随着血液全身循环3000次到4000次，把体内的癌细胞，老化细胞，病变细胞，细菌病毒等杀灭一遍，从而达到防癌抗癌，提升免疫力，延长生存期的目的。

portant; word-wrap: break-word 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portant; word-wrap: break-word 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高活化NK细胞疗法的特点

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">1几乎无毒副作用

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">由于从患者血液中收集NK细胞培养和激活，因此无需担心排斥反应或过敏反应。它可以说是一种对身体没有任何伤害的疗法。偶尔出现回输后发热症状，也不用担心，因为这是体内在增加免疫力的过程中出现的正常反应，取决于个体差异，但通常会在一天内消退。

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">2有效预防复发和转移

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">高度活化的NK细胞疗对复发和转移非常有效，因为整个身体的NK细胞被大量激活。特别是手术后，癌细胞通过血流和淋巴流传播到全身的风险很高，这时通过高度活化NK细胞治疗可以有效清除手术不能完全切除的肿瘤细胞，对预防复发非常有效。

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">3协同疗效，降低副作用

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">因为它可以与手术，化疗和放疗三种主要疗法联合使用，可以增加治疗效果，降低副作用。

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">4保持高质量的生活

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">手术，放化疗都有强烈副作用，需要患者长期住院，但高度激活的NK细胞治疗几乎没有身心负担，可以通过门诊治疗，因此，可以在不改变当前生活节奏的情况下进行治疗。因此，可以保持很高的生活质量（QOL）。

哪些癌症患者适合接受NK细胞疗法？

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">虽然它作为一种新的癌症治疗方法引起了极大的关注，这种治疗方法副作用很小，可以在保持高质量生活（QOL）的同时进行治疗。但需要患者注意的是，细胞免疫治疗绝对不是一种适用于任何患者的神奇疗法，对于晚期癌症患者肿瘤的缩小效果不明显，只能在保持生活品质的同时尽量达到延长寿命的效果，并且研究显示，与化疗、靶向药、PD1抑制剂等其它疗法联合治疗，效果会更佳。

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">这几类患者比较适合：

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• 肿瘤手术前体质较差，术后恢复慢，且害怕隐匿性癌细胞没有被彻底根除的患者。

• 放疗、化疗后，免疫力低下，副作用反应明显(如食欲减退、恶心、脱发、皮肤炎症等),期望增加化放化疗效果的患者。

• 由于害怕放化疗的毒副作用，希望利用各种治疗手段实现治疗效果的患者。

• 肿瘤晚期癌细胞已经全身扩散，但常规治疗方法已无能为力，期望延长生存期，提高生活质量的患者。

NK细胞疗法的治疗过程

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;"> 

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">1.采血

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">抽取癌症患者外周血30-50ml，提取单个核细胞；

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">2.实验室培养

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">在实验室，使用称为白细胞介素-2的细胞因子扩增并活化分离的NK细胞；

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">3.回输

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">在为期两周的培养期后，NK细胞的数量将增加数百至数千倍，像输液一样回输给癌症患者。（培养后NK细胞的数量约为10亿。为正常健康人NK细胞数量的10倍。具体取决于培养期和患者情况。）

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国内患者如何接受NK细胞治疗？

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">作为较早进军免疫治疗的国家，日本是国际上率先批准使用免疫疗法的国家之一。目前，中国和美国都在积极开展NK细胞治疗实体瘤的临床试验，但尚未正式批准进入临床使用。

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seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">大家可以通过全球肿瘤医生网进行评估（）进行NK细胞疗法或者加入临床试验。

NK细胞杀伤功能如何实现的？

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">NK细胞杀伤外来异物主要通过以下4个途径完成，分别是：

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">1.直接杀伤

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">NK细胞直接通过胞吐作用释放穿孔素和颗粒酶等细胞毒性颗粒，穿孔素在靶细胞表面穿孔，使颗粒酶b进入靶细胞诱导靶细胞凋亡。

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">2.诱导细胞凋亡

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">活化NK细胞表达Fas（CD95）配体和TRAIL（TNF related apoptosis inducing ligand，肿瘤坏死因子相关诱导凋亡配体）分子，诱导CD95+靶细胞和TRAIL受体阳性的靶细胞通过内源酶的级联反应发生凋亡，使靶细胞进入程序性凋亡状态。

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font-style: inherit; font-variant: inherit; font-weight: inherit; font-stretch: inherit; font-size: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; word-break: break-word; display: block; border-radius: 4px; box-sizing: border-box !important; word-wrap: break-word !important; height: 165px !important; width: 306px !important;" alt="" />

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;"> 

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seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">3.细胞因子介导杀伤

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">NK细胞能合成和分泌多种细胞因子，如IFN-γ、TNF-α、IL1、IL5、IL8、IL10和G-CSF等，直接作用于靶细胞，或通过进一步激活其他种类免疫细胞攻击靶细胞。

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">4. 抗体依赖性细胞介导的细胞毒性作用（ADCC）

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">NK 细胞低亲和力的 CD16 分子与靶细胞 IgG 抗体复合物结合后，活化蛋白酪氨酸激酶（PTK），使 PLC γ 的酪氨酸磷酸化，裂解膜磷酯酰肌醇为三磷酸肌醇（IP3）和二酰甘油，IP3增加细胞内游离钙浓度，进而释放细胞毒性物质（如穿孔素和颗粒酶）。

结语

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">随着医疗技术的快速进步，癌症已经不再是不治之症，如果选择了正确的治疗方案，并且积极接受治疗，仍然有无进展生存的机会！

seline; word-break: break-word; color: rgb(93, 93, 93); box-sizing: border-box !important; word-wrap: break-word !important;">癌症治疗除了手术、放疗、化疗外，近年来靶向治疗，免疫治疗包括细胞免疫治疗取得了重大突破，为癌症的综合治疗添砖加瓦，终有一天，我们会战胜癌症！

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portant; word-wrap: break-word !important;">http://www.hu-clinic.com/case/case_21.html